Caged at red
Size: 100 μl
Concentration: 1 mM
The active form of the prodrug AZT. Inhibits telomerase activity in vitro
= 30 μM) and is incorporated into telomeric DNA, blocking chain elongation and causing irreversible telomere shortening (i.e. artificial senescence). Has 100- to 300-fold greater affinity for HIV reverse transcriptase, as compared to human DNA polymerase. Mitochondrial DNA synthesis is relatively susceptable (DNA polymerase gamma). It's inhibitory effect is greater during the initiation phase of reverse transcription.
Mickle, T., and Nair, V. 2000. Antimicrob. Agents Chemother. 44, 2939. Rigourd, M., et al. 2000. J. Biol. Chem. 275, 26944. Murakami, J., et al. 1999. Eur. J. Cancer 35, 1027. Strahl, C., and Blackburn, E.H. 1996. Mol. Cell. Biol. 16, 53. Strahl, C., and Blackburn, E.H. 1994. Nucleic Acids Res. 22, 893.