Caged at red
Size: 100 μl
Concentration: 1 mM
A cell-permeable inhibitor of topoisomerase II (IC50
= 3.3 μM). At a concentration (1 μM) that does not cause cell death, restores functional wild-type p53 activity via inhibition of mutant p53 protein phosphorylation. Suppresses Cdk2 activity in a concentration-dependent manner. Also reported to inhibit telomerase activity in cultured pancreatic cells at 10 μM (no inhibition at 1-3 μM), possibly through inhibition of protein kinases. Binds to the aryl hydrocarbon receptor (AhR) in rat lung cytosol and inhibits aryl hydrocarbon hydroxylase (AHH) activity in rat hepatic microsomes.
Mizumoto, K., et al. 2000. Cancer Lett. 149, 85. Perry, P.J., et al. 1999. Anticancer Drug Des. 14, 373. Sugikawa, E., et al. 1999. Anticancer Res. 19, 3099. Sato, N., et al. 1998. FEBS Lett. 441, 318. Ohashi, M., et al. 1995. Jpn. J. Cancer Res. 86, 819. Renault, G., et al. 1987. Toxicol. Appl. Pharmacol. 89, 281.