Caged at red
Size: 100 μl
Concentration: 1 mM

A cell-permeable inhibitor of topoisomerase II (IC₅₀ = 3.3 μM). At a concentration (1 μM) that does not cause cell death, restores functional wild-type p53 activity via inhibition of mutant p53 protein phosphorylation. Suppresses Cdk2 activity in a concentration-dependent manner. Also reported to inhibit telomerase activity in cultured pancreatic cells at 10 μM (no inhibition at 1-3 μM), possibly through inhibition of protein kinases. Binds to the aryl hydrocarbon receptor (AhR) in rat lung cytosol and inhibits aryl hydrocarbon hydroxylase (AHH) activity in rat hepatic microsomes.

References

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